Increasing demands for lightweight, high performance materials has put Carbon Fibre Composite (CFC) and titanium alloys at the forefront in many industries. In drilling, CFC and Ti-alloys are commonly recognized as difficult to machine materials. Therefore, a new alternative to replace the conventional drilling of these materials is highly desirable. Here, we studied Ultrasonic Assisted Drilling (UAD) of CFC/Ti stacks. The UAD technique has shown positive influence to enhance tool wear resistance with a significant reduction in thrust force and torque. The life of Tungsten Carbide (WC) drills has improved by 300 %. Owing to the reduction of titanium adhesion and flank wear, it is possible to decrease cutting temperatures since vibrating the cutting tool during drilling led to improved evacuation of the hot titanium chips from the cutting zone consequently facilitating cutting tool cooling.