NICE is a short form of Nanomaterials Integration Competence Centre with the main activities of product development using a transdisciplinary approach and integration of science and engineering. NICE was established with the collaboration of some experts of NanoRG and CREAM (Central Research and Animal Facility) and RUBIC (Research Unit for Bioinformatics & Computational Biology) at the Kulliyyah of Science, IIUM Kuantan. The pioneering work was the rapid kit test kit for Covid-19 pandemic. In the Industrial Revolution 4.0 (IR4.0), the predictive and precision technology resulting from predictive simulation tools in computational chemistry, materials modelling and biological simulations have powered the system integration of nanomaterials into advanced materials which are essential in the development of a portable, low cost, precise, and effective diagnostic.